Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms

Autor: Khatcher O. Margossian, Marcel U. Brown, Todd Emrick, Murugappan Muthukumar
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29851-y
Popis: Coacervation is widely studied as potential drug delivery platform, but formation of coacervates at lower pH ranges, such as found in the gastrointestinal tract, remains challenging. Here, using theory and experimental methods, the authors demonstrate the formation of a polyzwitterionic complex, formed by coacervation of a polyzwitterion and a polyelectrolyte, exhibiting orthogonal phase behavior under physiological low pH conditions.
Databáze: Directory of Open Access Journals
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