| Autor: |
Janine Pilcher, Darmiga Thayabaran, Stefan Ebmeier, Mathew Williams, Geraldine Back, Hamish Collie, Michael Richards, Susan Bibby, Ruth Semprini, Mark Weatherall, Richard Beasley |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2466 |
| DOI: |
10.1186/s12890-020-1132-z |
| Popis: |
Abstract Background High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO2) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective of these studies was to investigate whether this physiological response to oxygen therapy occurs in stable patients with neuromuscular disease or kyphoscoliosis, and bronchiectasis. Methods Three randomised cross-over trials recruited stable patients with neuromuscular disease or kyphoscoliosis (n = 20), bronchiectasis (n = 24), and COPD (n = 24). Participants were randomised to receive 50% oxygen and 21% oxygen (air), each for 30 min, in randomly assigned order. The primary outcome was transcutaneous partial pressure of carbon dioxide (PtCO2) at 30 min. The primary analysis was a mixed linear model. Results Sixty six of the 68 participants had baseline PtCO2 values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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