Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture

Autor: Wen Zeng, Yong Chen, Bolong Yin, Xue Wen, Jian Xiao, Lian Luo, Haiyuan Tang, He Zheng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: The Saudi Journal of Gastroenterology, Vol 30, Iss 2, Pp 108-113 (2024)
Druh dokumentu: article
ISSN: 1319-3767
1998-4049
DOI: 10.4103/sjg.sjg_256_23
Popis: Background: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. Methods: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used. Results: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1–5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery. Conclusion: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future.
Databáze: Directory of Open Access Journals
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