| Autor: |
Tina D. Kristensen, Karen S. Ambrosen, Jayachandra M. Raghava, Warda T. Syeda, Thijs Dhollander, Cecilie K. Lemvigh, Kirsten B. Bojesen, Anita D. Barber, Mette Ø. Nielsen, Egill Rostrup, Christos Pantelis, Birgitte Fagerlund, Birte Y. Glenthøj, Bjørn H. Ebdrup |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Schizophrenia, Vol 10, Iss 1, Pp 1-9 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2754-6993 |
| DOI: |
10.1038/s41537-024-00487-9 |
| Popis: |
Abstract Patients with schizophrenia exhibit structural and functional dysconnectivity but the relationship to the well-documented cognitive impairments is less clear. This study investigates associations between structural and functional connectivity and executive functions in antipsychotic-naïve patients experiencing schizophrenia. Sixty-four patients with schizophrenia and 95 matched controls underwent cognitive testing, diffusion weighted imaging and resting state functional magnetic resonance imaging. In the primary analyses, groupwise interactions between structural connectivity as measured by fixel-based analyses and executive functions were investigated using multivariate linear regression analyses. For significant structural connections, secondary analyses examined whether functional connectivity and associations with executive functions also differed for the two groups. In group comparisons, patients exhibited cognitive impairments across all executive functions compared to controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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