Assessment of Reactogenicity and Immunogenicity of the Quadrivalent Live Attenuated Influenza Vaccine

Autor:	D. A. Lioznov, S. M. Kharit, M. K. Erofeeva, T. G. Zubkova, O. V. Gorchakova, S. L. Nikolaenko
Jazyk:	ruština
Rok vydání:	2018
Předmět:	clinical trial quadrivalent inactivated subunit influenza vaccine immunogenicity safety Epistemology. Theory of knowledge BD143-237
Zdroj:	Эпидемиология и вакцинопрофилактика, Vol 17, Iss 3, Pp 57-62 (2018)
Druh dokumentu:	article
ISSN:	2073-3046 2619-0494
DOI:	10.31631/2073-3046-2018-17-3-57-62
Popis:	In this multicenter double blind randomized clinical study with parallel groups conducted with 612 healthy volunteers, domestic influenza quadrivalent inactivated subunit vaccine Grippol® Quadrivalent safety, tolerability and immunogenicity was evaluated in comparison with seasonal trivalent vaccines, It was demonstrated that quadrivalent influenza vaccine Grippol® Quadrivalent possesses good tolerability, low reactogenicity, and has favorable safety profile similar to that for trivalent comparators. Besides, it was proven that quadrivalent influenza vaccine Grippol® Quadrivalent has same immunogenicity for three conventional strains and significantly exceeds trivalent comparators for missed influenza B strain.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/71ef60e02c6e4ba48ee0fdd62eefa756 Zobrazit plný text záznamu View record in DOAJ