Resveratrol modulates signalling to inhibit vascular smooth muscle cell proliferation induced by angiotensin II and high glucose

Autor: Çetin Arzu, Kırça Mustafa, Yeşilkaya Akın
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Türk Biyokimya Dergisi, Vol 49, Iss 3, Pp 455-462 (2024)
Druh dokumentu: article
ISSN: 1303-829X
DOI: 10.1515/tjb-2023-0191
Popis: The proliferation of vascular smooth muscle cells (VSMCs) induced by hyperglycemia plays a pivotal role in the development of atherosclerosis and restenosis. This study aims to examine the impact of angiotensin II (Ang II) and high glucose on VSMC proliferation and the phosphorylation status of key signalling proteins, specifically ERK1/2, Akt, and STAT3. Furthermore, we assess the inhibitory effects of resveratrol, a polyphenolic compound, on these signalling pathways.
Databáze: Directory of Open Access Journals