Submandibular gland amyloidosis: A rare manifestation of extranodal marginal lymphoma – A case report and literature review

Autor: N. Chargi, T. Verhoeven, E. Dik, C. Coppen, L.L. van den Hoogen, W.B.C. Stevens, K.M. Hebeda, W. Weijs
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Oral and Maxillofacial Surgery Cases, Vol 10, Iss 1, Pp 100342- (2024)
Druh dokumentu: article
ISSN: 2214-5419
DOI: 10.1016/j.omsc.2023.100342
Popis: Amyloidosis of the submandibular gland is a rare manifestation of extranodal marginal zone lymphoma (eMZL). Here, we present a case-report of a 62-year-old female patient with a history of eMZL, limited stage IIEA. The patient was initially treated with radiotherapy; however large glands remained with lack of clinical response to the radiotherapy. Consequently, a surgical excision of the submandibular glands was performed, and histology revealed massive amyloid deposits in the gland tissue next to eMZL. This case report highlights the importance of considering amyloidosis as a possible cause of submandibular gland enlargement in patients with a history of lymphoma and emphasizes the need for a histological diagnosis to direct appropriate treatment.
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