Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions

Autor:	Vadim V. Semashko, Maksim S. Pudovkin, Alkiviadis-Constantinos Cefalas, Pavel V. Zelenikhin, Vassilios E. Gavriil, Alexei S. Nizamutdinov, Zoe Kollia, Angelo Ferraro, Evangelia Sarantopoulou
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Physics of cancer Tumorigenesis Cancer and nanoparticles Mechanotransducers Mechanosensors Integrins Materials of engineering and construction. Mechanics of materials TA401-492
Zdroj:	Nanoscale Research Letters, Vol 13, Iss 1, Pp 1-24 (2018)
Druh dokumentu:	article
ISSN:	1931-7573 1556-276X
DOI:	10.1186/s11671-018-2775-z
Popis:	Abstract Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF3 and PrF3 nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/71eb7806249a474f902d71ddffbf7809 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ