| Autor: |
Xi Chen, Jing Wang, Liang Ge, Gang Lu, Hailin Wan, Yeqing Jiang, Zhenwei Yao, Gang Deng, Xiaolong Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Brain and Behavior, Vol 12, Iss 2, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2162-3279 |
| DOI: |
10.1002/brb3.2474 |
| Popis: |
Abstract Objective To investigate the relationship between fibrin deposition and “no‐reflow” within microcirculation after thrombolysis in acute ischemic stroke (AIS). Materials and methods Experiments were approved by the institutional animal care and use committee. An experimental AIS model was induced in C57BL/6 mice by middle cerebral artery occlusion (MCAO) via the photothrombotic method. Mice were randomly assigned to non‐thrombolytic or thrombolytic treated groups (n = 12 per group). The modified Neurological Severity Score and Fast Beam Balance Test were performed by a researcher blinded to the treatment method. MRI was utilized to evaluate all of the mice. An FXIIIa‐targeted probe was applied to detect fibrin deposition in acute ischemic brain regions by fluorescence imaging. Necrosis and pathological changes of brain tissue were estimated via Hematoxylin and eosin staining while fibrin deposition was observed by immunohistochemistry. Results Thrombolytic therapy improved AIS clinical symptoms. The infarct area of non‐thrombolytic treated mice was significantly greater than that of the thrombolytic treated mice (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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