Bioavailability of butorphanol after intranasal administration to horses.
| Autor: | V. Ferreira, M. I. Velloso, M. F. Landoni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Bulgarian Journal of Veterinary Medicine, Vol 23, Iss 4, Pp 443-447 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1311-1477 1313-3543 |
| DOI: | 10.15547/bjvm.2019-0051 |
| Popis: | The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of butorphanol were measured at predetermined time points using liquid chromatography/mass spectrometry assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butorphanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses. |
| Databáze: | Directory of Open Access Journals |
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