| Autor: |
Loredana Ricciardi, Sharmistha Chatterjee, Giovanna Palermo, Elisabeta I. Szerb, Alessia Sanna, Francesca Palermo, Nicola Pieroni, Michela Fratini, Roberto Bartolino, Alessia Cedola, Massimo La Deda, Giuseppe Strangi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Nanotheranostics, Vol 3, Iss 1, Pp 1-17 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2624-845X |
| DOI: |
10.3390/jnt3010001 |
| Popis: |
Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies of GBM treatments based on photo-nanotherapeutics to activate synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining photophysical properties of a new generation PDT agent (Ir(III) complex) with the thermoplasmonic effects of resonant gold nanospheres. In order to investigate the damages induced in GBM treated with these photoactivable nanosystems, we employed X-ray phase-contrast tomography (XPCT). This high-resolution three-dimensional imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is indicative of tumor elimination without relapse. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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