An Update on Clostridioides difficile Binary Toxin

Autor: Adrián Martínez-Meléndez, Flora Cruz-López, Rayo Morfin-Otero, Héctor J. Maldonado-Garza, Elvira Garza-González
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Toxins, Vol 14, Iss 5, p 305 (2022)
Druh dokumentu: article
ISSN: 2072-6651
21186286
DOI: 10.3390/toxins14050305
Popis: Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of C. difficile strains produce a binary toxin (CDT) encoded by the tcdA and tcdB genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje