Antimicrobial hard denture reliners using quaternary ammonium methacryloxy silicate (K18 QAMS) and K18-functionalized filler
| Autor: | Sara Bellusa, Lianrui Chu, Evelyn Fung, Kyumin Whang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Applied Biomaterials & Functional Materials, Vol 22 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2280-8000 22808000 |
| DOI: | 10.1177/22808000241284431 |
| Popis: | Objective: To determine the effects of adding a quaternary ammonium methacryloxy silicate (K18) and K18-functionalized filler (K18-Filler) on the material and antimicrobial properties of a hard denture reline material. Materials and methods: 30% K18 in methyl methacrylate (K18-MMA; 0–20 wt% of reliner) and K18-Filler (0–30 wt% of reliner) were incorporated into Kooliner TM hard denture reliner. Kooliner TM served as the control. The cure (Shore A hardness), hydrophilicity (contact angles), mechanical (3-point bend test), water sorption, and antimicrobial properties against Streptococcus mutans , S. sanguinis , and Candida albicans were determined. Results: Most K18 groups cured well and had comparable Shore A hardness values (range ~52 to 70 DHN) to that of controls (67.2 ± 1.8 DHN; Bonferroni corrected p > 0.0003). Even the softest group had hardness values within the range of commercial products. Half of the K18 groups had comparable contact angles to that of controls (range ~75° to 80° vs 83.41° ± 2.66°; Bonferroni corrected p > 0.0003), and most were within the range of commercial liners. K18-MMA and K18-Filler increased modulus but decreased ultimate transverse strength (UTS). All experimental groups had comparable or higher moduli than controls (range ~966 to 2069 MPa vs 1340 ± 119 MPa; Bonferroni corrected p 0.0003). The 15% and 20% K18-MMA with 30% K18-Filler groups had significant antimicrobial activity against all three microbes ( p 0.05). Conclusions: K18-MMA and K18-Filler are promising antimicrobial additives that produce hard denture liners with material properties within the range of commercial products and significant antimicrobial properties against S. mutans , S. sanguinis , and C. albicans . Further development is needed to reduce water sorption. |
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