Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes

Autor: Eitan Amir, Joseph Kim, Christopher Chan, Alejandro Meraz-Muñoz, Pamela Ng, Carmen Avila-Casado, Claire Ragobar, Ron Wald, Abhijat Kitchlu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Druh dokumentu: article
ISSN: 2051-1426
DOI: 10.1136/jitc-2019-000467
Popis: Background Immune checkpoint inhibitors (ICPi) are a novel and promising anti-cancer therapy. There are limited data on the incidence, risk factors and outcomes of acute kidney injury (AKI) in patients receiving ICPi.Methods We conducted a cohort study of patients receiving ICPi at our center between 2010 and 2017 via electronic health record. The primary outcome was AKI (increase of >50% from baseline serum creatinine (sCr)). Risk factors for AKI were assessed using logistic regression. Survival among those with and without AKI was compared using the Kaplan-Meier method.Results Among 309 patients on ICPi, 51 (16.5%) developed AKI (Kidney Disease Improving Global Outcomes (KDIGO) stages 1: 53%, 2: 22%, 3: 25%). AKI was associated with other immune-related adverse events (IRAE) (OR 3.2, 95% CI 1.6 to 6; p
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