Serological characteristics of HBsAg positive/HBV DNA non-reactive blood donors

Autor: Yuanyuan JING, Yun FAN, Yan GUO, Wenjuan ZHANG, Yong DUAN, Na FENG
Jazyk: čínština
Rok vydání: 2024
Předmět:
Zdroj: Zhongguo shuxue zazhi, Vol 37, Iss 4, Pp 412-416 (2024)
Druh dokumentu: article
ISSN: 1004-549X
1004-549x
DOI: 10.13303/j.cjbt.issn.1004-549x.2024.04.007&lang=en
Popis: Objective To explore the distribution of serological markers related to samples whose serological test results were inconsistent with HBV DNA test results among voluntary blood donors in Xi′an. Methods A total of 71 HBsAg ELISA positive and NAT non-reactive (ELISA+ /NAT-)blood samples were collected from Shaanxi Blood Center from November 1, 2022 to April 30, 2023. The serological markers of hepatitis B were detected by electrochemiluminescence method, and the HBV S region and C region gene fragments were amplified by nested-PCR. Results The positive rate of nested-PCR in double ELISA+ /NAT- group(n=30) was statistically higher than that of ELISA+ /NAT- group(n=41)(60% vs 24.4%, P
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