Nephroprotective Evaluation of Moringa oleifera & Beta vulgaris Leaves in Murine Methotrexate Induced Toxicity
| Autor: | Bushra Suhail, Shumaila Kanwel, Mudassara Saqib, Saadia Shahzad Alam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Proceedings, Vol 34, Iss 4, Pp 30-34 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1815-4905 2518-203X |
| DOI: | 10.47489/p000s344z767mc |
| Popis: | Introduction: Methotrexate has been used for treatment of multiple diseases. Chronic use of this drug can result in oxidative damage resulting in nephrotoxicity. Beta vulgaris and Moringa oleifera are well known herbs for their antioxidant properties, so they can have potential nephroprotective effect against MTX induced renal damage. Aims & Objectives: The study was designed to evaluate the therapeutic role of Moringa oleifera and Beta vulgaris leaves against MTX induced nephrotoxicity in rats. Place and duration of study: Time duration of our research project was 6 months. It was carried out in PGMI Lahore and FPGMI, Shaikh Zayed Medical Complex, Lahore. Material & Methods: 5 groups of 9 rats each were made. Group1 were maintained as healthy controls while Group II as diseased control Groups III, IV and V were administered daily p.o for 24 days 200mg /kg of Ethanolic Extract of Beta Vulgaris( EEBV),and 800 mg/kg Ethanolic Extract of Moringa oleifera (EEMO) and combination of extracts (100mg/kg EEBV+400mg/kg EEMO respectively. Nephrotoxicity was produced on 21st day via single i/p route injection of 20mg/kg MTX in all groups except Group 1. RFTs were performed on days 1, 21 and 24th day. Nephroprotection was determined by measuring serum urea, creatinine along with histopathological study of kidneys at study end. Results: EEBV provided significant neproprotection in group 3 which had significantly lower levels of creatinine as compared to group 2 with p-value |
| Databáze: | Directory of Open Access Journals |
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