Gut microbiota dysbiosis-related susceptibility to nontuberculous mycobacterial lung disease
| Autor: | Tzu-Lung Lin, Yen-Liang Kuo, Juo-Hsin Lai, Chia-Chen Lu, Chang-Tsu Yuan, Chi-Yu Hsu, Bo-Shiun Yan, Lawrence Shih-Hsin Wu, Ting-Shu Wu, Jann-Yuan Wang, Chong-Jen Yu, Hsin-Chih Lai, Jwu-Ching Shu, Chin-Chung Shu |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Gut Microbes, Vol 16, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 19490976 1949-0984 1949-0976 |
| DOI: | 10.1080/19490976.2024.2361490 |
| Popis: | The role of gut microbiota in host defense against nontuberculous mycobacterial lung disease (NTM-LD) was poorly understood. Here, we showed significant gut microbiota dysbiosis in patients with NTM-LD. Reduced abundance of Prevotella copri was significantly associated with NTM-LD and its disease severity. Compromised TLR2 activation activity in feces and plasma in the NTM-LD patients was highlighted. In the antibiotics-treated mice as a study model, gut microbiota dysbiosis with reduction of TLR2 activation activity in feces, sera, and lung tissue occurred. Transcriptomic analysis demonstrated immunocompromised in lung which were closely associated with increased NTM-LD susceptibility. Oral administration of P. copri or its capsular polysaccharides enhanced TLR2 signaling, restored immune response, and ameliorated NTM-LD susceptibility. Our data highlighted the association of gut microbiota dysbiosis, systematically compromised immunity and NTM-LD development. TLR2 activation by P. copri or its capsular polysaccharides might help prevent NTM-LD. |
| Databáze: | Directory of Open Access Journals |
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