| Popis: |
Background: This study was performed with aim to analyze differentiated thyroid carcinoma (DTC) in patients staged as pathological T4 (pT4), related to the DTC patients staged as pT1-pT3. Methods: 267 patients staged as pT1-pT4 were treated in a period from 1977 to 2000, and followed until the end of 2001. Out of the total number, 117 patients were staged as pT4, 49 patients as pT3, 78 patients as pT2, and 23 patients as pT1. All patients were treated surgically, by radioiodine and by hormonal therapy; some of them underwent external radiotherapy and/or chemotherapy. Results: We staged 36 male and 81 female patients. pT4: 98 patients with papillary carcinoma (PAP), and 19 patients with follicular (FOL) DTC. In pT4 stage regional metastases (N1) were found in 68 patients, distant metastases (M1) in 21 patients, and disease related lethal outcome occurred in 10 patients. In pT1 stage N1 were present in 21 patients, M1 in 2 patients, and lethal outcome in 2 patients; in pT2 stage N1 was present in 37 patients, M1 in 8 patients and lethal outcome in 5 patients; in pT3 stage N1 were present in 14 patients, M1 in 11 patients, and lethal outcome in 5 patients. Regional metastases of DTC patients were significantly more frequent in pT4 stage than in DTC patients staged as pT2 and pT3, but they were significantly more frequent in pT1 stage (p |
