Effect of Topical Mitomycin C as an Adjunct to Dilation Therapy in Esophageal Strictures
| Autor: | Zunaira Hameed, Muhammad Tariq Aziz, Muhammad Aslam Sheikh, Saima Jabeen Joiya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Pakistan Journal of Medicine and Dentistry, Vol 13, Iss 3 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2313-7371 2308-2593 |
| DOI: | 10.36283/PJMD13-3/007 |
| Popis: | Background: The treatment of choice for most esophageal strictures is esophageal dilatation but it has a low success rate. This study was conducted to determine the effect of topical mitomycin C as an adjunct to dilatation therapy in esophageal strictures among children. Methods: This randomized controlled trial was conducted at the Department of Pediatric Gastroenterology, The Children’s Hospital and Institute of Child Health, Multan, Pakistan, from July 2022 to October 2023. Children aged 1-12 years and having esophageal strictures were included. A simple random sampling technique was adopted. Children in the Mitomycin C group received topical mitomycin C (2 mg/20 ml saline) during the endoscopy, whereas the placebo group received normal saline. The counts of dilatation sessions necessary in each group and the proportion of patients who were symptom-free after 12 months of therapy were noted (outcome). IBM-SPSS 26 was used for data analysis with p |
| Databáze: | Directory of Open Access Journals |
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