| Autor: |
Vien X. Nguyen, Cuong C. Nguyen, Jonathan A. Leighton, Shabana F. Pasha, Alvin C. Silva, Jacques P. Heppell, Giovanni De Petris |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Case Reports in Gastroenterology, Vol 4, Iss 1, Pp 66-70 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1662-0631 |
| DOI: |
10.1159/000255981 |
| Popis: |
Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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