Pulmonary emphysema induced by passive smoking: an experimental study in rats
| Autor: | S.P. Cendon, C. Battlehner, G. Lorenzi-Filho, M. Dohlnikoff, P.M. Pereira, G.M.S. Conceição, O.S. Beppu, P.H.N. Saldiva |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 30, Iss 10, p 1241 (1997) |
| Druh dokumentu: | article |
| ISSN: | 0100-879X 1414-431X |
| DOI: | 10.1590/S0100-879X1997001000017 |
| Popis: | We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P |
| Databáze: | Directory of Open Access Journals |
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