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The aim of our work was to identify the relationship between platelet amino acid profile and cardiometabolic risk factors in patients with coronary heart disease and atrial fibrillation. 300 patients were examined, who were divided into 3 groups: the first (I) – 149 patients with coronary artery disease (CAD) and without arrhythmias, the second (II) – 123 patients with CAD and paroxysm of atrial fibrillation (AF) and the control group (CG) – 28 patients without CAD and arrhythmia. The platelets amino acid (AA) profile was determined by ion exchange liquid column chromatography. Cardiometabolic risk factors studied: total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), lipoprotein α (Lpα), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), C-reactive protein (CRP), interleukin-6 (IL-6), trimethylamine (TMA) and trimethylamine-N-oxide (TMAO). Significant increase of isoleucine (10.73%), leucine (12.63%) and decrease of threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels in platelet AA profile was observed in patients with CAD and AF compared to patients with CAD without arrhythmias, p |
