EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
| Autor: | Muhammad Siddique Kakar, Mansoor Mustafa, Haroon Khattak, Syed Khurram Naseer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Pakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1332-1336 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0030-9648 2411-8842 |
| Popis: | Objective: To evaluate the effect of a single dose of Ketamine in treatment of severe Major Depressive Disorder MDD in Pakistani patients. Study Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at Combined Military Hospital, Gilgit, from Apr 2017 to Mar 2018. Methodology: Twenty nine subjects for this study had a primary diagnosis of severe Major Depressive disorder with a score of more than 19 on the HAM-D (Hamilton rating scale for depression) scale. These patients were divided into two groups. Group A received injection ketamine IV whereas group B received placebo 0.9% normal saline. Both were reassessed after 24 hours and there HAM-D scores were measured again. Results: Out of the total 29 patients, response was present in 14 (48.2%) and 15 (51.8%) did not respond to the treatment. Out of 19 patients that were treated with ketamine, 12 (63.1%) showed response to treatment while 7 (36.9%) did not respond. Out of 10 patients that were treated with placebo, 2 (20%) showed response to treatment while 8 (80%) did not respond. The p-value with a confidence interval of 95% was 0.033 showing that the difference in the two treatments was statistically significant. Conclusion: Ketamine demonstrated rapid antidepressant effects in this study, further supporting N-methyl-Daspartate (NMDA) receptor modulation as a novel mechanism for accelerated improvement in severe forms of depression. However further trials are needed to establish long term effects of the drug. |
| Databáze: | Directory of Open Access Journals |
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