| Autor: |
María G Guzmán, Lissette Pérez, Yahisel Tejero, Dailyn Mederos, Mirtha E. Aguado, Yanet Pintos, Odalys Valdes, Mayling Álvarez, Liena de Regla Ponce de León, Waldemar Baldoquín, Yenisleidys Martínez, Claudia Figueredo, Celine Naranjo, Lirialys Nuñes, Yanaris López Almaguer, José R de Armas Fernández, José A Portal Miranda, Vivian Kourí |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical Virology Plus, Vol 2, Iss 4, Pp 100104- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0380 |
| DOI: |
10.1016/j.jcvp.2022.100104 |
| Popis: |
The SARS CoV-2 D614G variant circulated in Cuba in 2020. New viral variants were detected after the opening of the border in November 2020. We show the results of the genomic surveillance in Cuba from December 28, 2020, to September 28, 2021 and their relationship to the epidemiological situation in the country. A total of 1,406 nasopharyngeal exudates from COVID-19 patients were processed for RNA extraction and the 1836 bp fragment of the spike gene was amplified and sequenced. The mutations present were determined using the GISAID database. Prevalence ratios were estimated by fitting Poisson univariate and multivariate regression models to investigate associations between SARS-CoV-2 variant group (VOC, non-VOC) and disease outcome. Seventeen genetic variants were detected including VOC Alpha, Beta, Gamma and Delta, one variant of interest (VOI) (Lambda) and two previous VOI (A.2.5.1 and Zeta/P.2). Beta (34.77%), Delta (24.89%) and D614G (19%) variants were the most frequently detected. By June, Delta increased in frequency, displacing Beta. Disease severity increased significantly with age and VOC (PR =1.98, IC 95%: 1.33–3.05, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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