Meta-Analysis of Aidi Injection and First-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy in Treating Advanced Non-Small Cell Lung Cancer
| Autor: | Na Xiao MD, Hailang He MD, Jing Wang MD, Li Zhang MD, Brandon Chow, Fanchao Feng MD, Yong Xu MD, Jingyi Huang MD, Xianmei Zhou MD, Rui Dong MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Evidence-Based Integrative Medicine, Vol 26 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2515-690X 2515690X |
| DOI: | 10.1177/2515690X211010733 |
| Popis: | The combination of Aidi injection (ADI) and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in treating non-small cell lung cancer (NSCLC) has been reported, but the effects of this therapy have not been systematically assessed. Randomized controlled trials (RCTs) published before June 2020 were searched from 6 databases. Two reviewers independently assessed the methodological quality of 8 RCTs involving 667 patients diagnosed with stage III-IV NSCLC. We found that ADI combined with EGFR-TKI increased the objective response rate (ORR) significantly (relative risk [RR]: 1.60; 95% confidence interval [CI]: 1.28-1.99, P < 0.0001). There was also improvement in the disease control rate (DCR) (RR: 1.25; 95% CI: 1.11-1.40, P = 0.0002) as compared with EGFR-TKI alone. This therapy also increased the percentage of CD3 + cells (weighted mean difference [WMD]: 9.86; 95% CI: 4.62-15.10), CD4 + cells (WMD: 6.10; 95% CI: 1.67-10.53), and the CD4 + /CD8 + (WMD: 0.35; 95% CI: 0.28-0.43). With regard to drug toxicity, the occurrence of rash was significantly reduced by ADI combined with EGFR-TKI (RR: 0.78, 95% CI: 0.63-0.97, P = 0.03); however, we did not find a significant reduction in the occurrence of dry skin, nausea and vomiting, as well as diarrhea between the 2 therapies. ADI combined with first-generation EGFR-TKIs may be more effective in improving tumor response, reducing the occurrence of rash, and enhancing immune function in NSCLC than EGFR-TKI alone. |
| Databáze: | Directory of Open Access Journals |
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