| Autor: |
Zarife Nigâr Ozdemir-Kumral, Tuğçe Akgün, Ceren Haşim, Ezgi Ulusoy, Mehmet Kaan Kalpakçıoğlu, Muhammet Ferzan Yüksel, Tunahan Okumuş, Zeynep Us, Dilek Akakın, Meral Yüksel, Zafer Gören, Berrak Ç. Yeğen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Neuroscience, Vol 25, Iss 1, Pp 1-15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2202 |
| DOI: |
10.1186/s12868-024-00884-x |
| Popis: |
Abstract Background Status epilepticus is a common and potentially life-threatening neurological emergency with a high risk for cognitive and neurobiological impairment. Our aim was to evaluate the neuroprotective effects of centrally administered irisin and acute exhausting exercise against oxidative brain injury and memory dysfunction due to a pentylenetetrazole (PTZ)-induced single seizure. Male Sprague Dawley rats with intracerebroventricular (icv) cannulas were randomly divided into intraperitoneally (ip) saline-injected control and PTZ-injected (45 mg/kg) seizure groups. Both the control and PTZ groups were then treated with irisin (7.5 µg/kg, 2 µl, icv), saline (2 µl, icv) or were forced to an acute bout of strenuous exercise before the ip injection of saline (control) or PTZ. Seizures were evaluated using the Racine score. To evaluate memory performance, a passive avoidance test was performed before and after PTZ injection. Following euthanasia at the 24th hour of seizure induction, brain tissues were removed for histopathological examination and for evaluating oxidative damage, antioxidant capacity, and neurotransmitter levels. Results Glutamate/GABA imbalance observed in PTZ rats was corrected by irisin administration (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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