5-Trifluoromethoxy-substituted Nicotinic Acid, Nicotinamide and Related Compounds
| Autor: | Taras M. Sokolenko, Yurii L. Yagupolskii |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Журнал органічної та фармацевтичної хімії, Vol 22, Iss 1, Pp 22-30 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2308-8303 2518-1548 |
| DOI: | 10.24959/ophcj.24.302435 |
| Popis: | A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed. A series of related compounds, for example, nicotinic aldehyde and nicotinic alcohol, have been synthesized. It has been shown that 3-bromo-5-trifluoromethoxypyridine is a convenient and efficient synthon for palladium-catalyzed coupling reactions. The trifluoromethoxy group has been found to be remarkably stable against hydroiodic acid in contrast to the methoxy group. |
| Databáze: | Directory of Open Access Journals |
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