Lung involvement in children with newly diagnosed rheumatic diseases: characteristics and associations

Autor: Hua Huang, Yabin Hu, Yufen Wu, Fei Ding, Xuemei Xu, Yingying Jin, Yanliang Jin, Yixiao Bao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1546-0096
DOI: 10.1186/s12969-022-00731-5
Popis: Abstract Background Pulmonary complications of rheumatic diseases may cause functional impairment and increase mortality. However, reports regarding detection of lung involvement in children with treatment-naive, newly diagnosed rheumatic diseases are scarce. Herein, we aimed to describe the characteristics of such patients and explore the association between lung involvement and rheumatic disease. Methods From January 2019 to June 2021, 48 pediatric patients with treatment-naive, newly diagnosed rheumatic diseases at Department of Rheumatology and Immunology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University were included with pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) findings, and 51 age-matched healthy controls were examined based on PFTs. Univariate and multivariable logistic regression analyses were used to investigate the clinical characters and laboratory parameters associated with lung involvement in these patients. Results Asymptomatic patients had a faster respiratory rate and a higher ratio of forced expiratory volume in 1 s/forced vital capacity than the controls (P
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