| Autor: |
Bruna Romana-Souza, Andréa Monte-Alto-Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 54, Iss , Pp 310-319 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.01.036 |
| Popis: |
The aim of this study was to investigate whether oral administration of olive oil could attenuate chronic stress-induced signs of aging in mouse skin. The mice were subjected to daily rotational stress and treated with olive oil until the time of euthanasia (28 days). Murine dermal fibroblast cultures were exposed to increased epinephrine levels plus olive oil. Olive oil reduced catecholamine synthesis in the stressed mice. Moreover, olive oil inhibited stress-mediated increases in reactive oxygen species production, lipid peroxidation and protein carbonylation in mouse skin. Olive oil also inhibited stress-induced increases in matrix metalloproteinase-8 protein expression and collagen deposition in mouse skin. Additionally, olive oil reduced nuclear factor kappa B protein expression in the skin of stressed mice. In cultured dermal fibroblasts, olive oil abolished the increase in reactive oxygen species production and nuclear translocation of activated nuclear factor kappa B induced by high epinephrine levels. In conclusion, olive oil may attenuate stress-induced signs of aging in mouse skin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect