First seroepidemiological investigation of human enterovirus 71 in Iran
| Autor: | Mahsa Javadi, Ahmad Nejati, Maryam Yousefi, Mahmood Mahmoodi, Zabihollah Shoja, Shohreh Shahmahmoodi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Iranian Journal of Microbiology, Vol 13, Iss 4 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2008-3289 2008-4447 |
| DOI: | 10.18502/ijm.v13i4.6975 |
| Popis: | Background and Objectives: Human Enterovirus 71 (EV-A71) is the causative agent for many dermal to neurological diseases especially polio-like paralysis outbreaks around the world. This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT). Materials and Methods: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complete titration to determine the exact titer of anti-EV-A71 antibodies. Results: Of 547 samples, 310 (56.7%) were positive for EV-A71 neutralizing antibody. The presence of the antibody increased with age (p |
| Databáze: | Directory of Open Access Journals |
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