Preliminary monosodium glutamate-induced changes in mammary gland receptors and gene expression, water channel, oxidative stress, and some lactogenic biomarkers in lactating rats

Autor: Nachamada Solomon Emmanuel, Ibrahim Gaya Bako, Ibrahim Samaila Malgwi, Yusuf Tanko, Ejike Daniel Eze, Hajara Ali Umar, Munira Aliyu, Abdulmalik Muhammad, Aliyu Mohammed
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Basic and Applied Zoology, Vol 85, Iss 1, Pp 1-15 (2024)
Druh dokumentu: article
ISSN: 2090-990X
DOI: 10.1186/s41936-024-00354-0
Popis: Abstract Background Changes induced by monosodium glutamate (MSG) can negatively impact milk production and secretion, among other adverse effects. This study aimed to investigate the effects of MSG consumption on receptor gene expression and quantification of hormones and receptors, as well as oxidative stress biomarkers and other lactogenic parameters in lactating animals. Twenty-four female Wistar rats, nine weeks of age, were randomly assigned to four groups, each containing six rats, at parturition. The rats in groups II, III, and IV were given varying doses of monosodium glutamate (MSG); while, group I was given distilled water and served as the control. The experimental period lasted two (2) weeks. Results The groups administered with MSG showed a significant decrease in mammary PRLR gene expression (p
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