Crystal Structure and Intermolecular Energy for Some Nandrolone Esters

Autor:	Liviu Mare, Marieta Muresan-Pop, Pompilia Mioara Purcea Lopes, Alexandru Turza, Gheorghe Borodi, Violeta Popescu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	nandrolone ester crystal structure intermolecular interaction solubility Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 20, p 7179 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28207179
Popis:	Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic–androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld surfaces analysis accompanied by evaluation of crystal energies and intermolecular interactions computation. Also, the solubility of the esters was investigated from a pharmaceutical perspective.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/71320a9e62424f91bf17404434ab2c8c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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