| Autor: |
Carolina Jardim, Diana Macedo, Inês Figueira, Gary Dobson, Gordon J. McDougall, Derek Stewart, Ricardo B. Ferreira, Regina Menezes, Cláudia N. Santos |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 32, Iss , Pp 333-346 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.03.010 |
| Popis: |
Oxidative stress is a key process in several diseases and a growing body of preclinical/clinical evidence has pushed forward the health benefits of (poly)phenols. The protective potential of Corema album and Arbutus unedo (Poly)phenol Digested Metabolites (PDM), generated after in vitro digestion was evaluated. Chemical alterations caused by the digestion led to alterations of compounds reactivity. A. unedo leaf PDM arose as the fraction conferring the highest protective activity to the wild type and oxidative stress-sensitive yap1 yeast strains challenged with H2O2. Our mechanistic studies disclosed the effect of A. unedo leaf PDM on cell redox homeostasis and mitochondrial function, and identified HAP4, SOD1, SOD2, GSH1 and GLR1 as mediators of cellular protection. Also, RPN4- and ATG8-associated protein clearance pathways were revealed as putative targets. Overall, these data suggest the nutraceutical potential of A. unedo leaf PDM as a functional food for human health. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect