| Autor: |
Michele Klain, Valeria Gaudieri, Mario Petretta, Emilia Zampella, Giovanni Storto, Carmela Nappi, Carlo Buonerba, Felice Crocetto, Rosj Gallicchio, Fabio Volpe, Leonardo Pace, Martin Schlumberger, Alberto Cuocolo |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Future Science OA, Vol 7, Iss 8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5623 |
| DOI: |
10.2144/fsoa-2021-0053 |
| Popis: |
Aim: To assess the value of bone scintigraphy and 18F-fluorocholine PET/computed tomography (CT) in predicting outcome in patients with prostate cancer and bone metastases treated with 223radium. Materials & methods: Retrospective analysis of 48 patients that underwent 223radium therapy. End points were pain relief and overall survival. Results: After therapy, pain relief was observed in 27 patients. Patients without pain relief had more bone lesions at PET/CT than at bone scintigraphy (pretherapy imaging mismatch). In 39 patients who completed treatment protocol, post-therapy alkaline phosphatase and pretherapy imaging mismatch were independent predictors of poor overall survival. Conclusion: Patients with more lesions at 18F-fluorocholine PET/CT than at bone scintigraphy had a poor prognosis. The combined imaging approach could be useful to predict outcome after 223radium therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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