Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets

Autor:	Tanja Spethmann, Lukas Clemens Böckelmann, Vera Labitzky, Ann‐Kristin Ahlers, Jennifer Schröder‐Schwarz, Sarah Bonk, Ronald Simon, Guido Sauter, Hartwig Huland, Robert Kypta, Udo Schumacher, Tobias Lange
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	cell adhesion CHD1 ERG junction plakoglobin prostate cancer WNT signaling Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular Oncology, Vol 15, Iss 7, Pp 1956-1969 (2021)
Druh dokumentu:	article
ISSN:	1878-0261 1574-7891
DOI:	10.1002/1878-0261.12922
Popis:	Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray containing 11 267 individual prostatectomy specimens. Considering all patients, high JUP expression was associated with adverse tumor stage (P = 0.0002), high Gleason grade (P
Databáze:	Directory of Open Access Journals
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