| Autor: |
Graciela Castro-Narro, Carlos Moctezuma-Velázquez, Rene Male-Velázquez, Rafael Trejo-Estrada, Francisco Javier Bosques, Rosalba Moreno-Alcántar, Heriberto Rodríguez-Hernández, Aleida Bautista-Santos, Carlos Córtez-Hernández, Eira Cerda-Reyes, Juanita Pérez-Escobar, Juan Manuel Aldana-Ledesma, Jonathan Aguirre-Valadez, José Antonio Velarde Ruiz-Velasco, Raúl Contreras-Omaña, Godolfino Miranda-Zazueta, Monica del Rocío Reyes-Bastidas, Javier Manuel Meza-Cardona, Norberto Chávez-Tapia, Nicolas Joaquín Fernández-Pérez, Edgar Santino García-Jiménez, Aldo Torre |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 27, Iss 4, Pp 100708- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2022.100708 |
| Popis: |
Cirrhosis is characterised by a prolonged asymptomatic period in which the inflammation persists, increasing as the disease progresses. Characteristic of this is the increase in pro-inflammatory cytokines and pro-oxidant molecules which are determining factors in the development of multiple organ dysfunction. In the early development of cirrhosis, splanchnic arterial vasodilation, activation of vasoconstrictor systems (renin-angiotensin-aldosterone) and the sympathetic nervous system (noradrenaline) bring about bacterial translocation and systemic dissemination via portal circulation of bacterial products, and molecular patterns associated with damage, which exacerbate the systemic inflammation present in the patient with cirrhosis. Albumin is a molecule that undergoes structural and functional changes as liver damage progresses, affecting its antioxidant, immunomodulatory, oncotic and endothelial stabilising properties. Our knowledge of the properties of albumin reveals a molecule with multiple treatment options in patients with cirrhosis, from the compensated then decompensated phases to multiple organ dysfunction. Its recognised uses in spontaneous bacterial peritonitis, post-paracentesis circulatory dysfunction, acute kidney injury and hepatorenal syndrome are fully validated, and a treatment option has opened up in decompensated cirrhosis and in acute-on-chronic liver disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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