Effect Of C-Phycocyanin on Soluble Globoprotein Content (Sgp130) on Trophoblas of Interleukin-6 (Il-6) Wistar Rat
| Autor: | Elizabeth Haryanti, Harry K Gondo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Jurnal Ilmiah Kedokteran Wijaya Kusuma, Vol 6, Iss 1, Pp 23-28 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1978-2071 2580-5967 |
| Popis: | The placenta is a joint organ of the uterus surface mother and fetus. One of cytokines of the placenta is IL-6 which is essential for normal placental development and successful pregnancy. Sgp130 binds Interleukin-6-sIL-6R complex, so Interleukin-6 signal cannot be passed on. Both factors play an important role in pre-eclampsia which has high levels of IL-6 and sgp130. They are expected to be suppressed by administration of C-phycocyanin. The aim of this study to prove effect of C-phycocyanin on sgp130 levels among wistar rats’ trophoblasts exposed to IL-6. The design of the study was Experiment, Post Test Only Control, analyse with One way Anova. The samples were 25 rats divided four treatment groups. Dose of C-Phycocyanin (10mg, 20mg, 40mg). The results significant difference between control and treatment group IL-6, IL-6 + CPC10, IL-6 + CPC20. But there was no significant difference between control group and IL-6 + CPC40, sig value. 0.214 (sig. |
| Databáze: | Directory of Open Access Journals |
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