Estimation of probability distributions of parameters using aggregate population data: analysis of a CAR T-cell cancer model

Autor: Celia Schacht, Annabel Meade, H.T. Banks, Heiko Enderling, Daniel Abate-Daga
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Mathematical Biosciences and Engineering, Vol 16, Iss 6, Pp 7299-7326 (2019)
Druh dokumentu: article
ISSN: 1551-0018
DOI: 10.3934/mbe.2019365?viewType=HTML
Popis: In this effort we explain fundamental formulations for aggregate data inverse problems requiring estimation of probability distribution parameters. We use as a motivating example a class of CAR T-call cancer models in mice. After ascertaining results on model stability and sensitivity with respect to parameters, we carry out first elementary computations on the question how much data is needed for successful estimation of probability distributions.
Databáze: Directory of Open Access Journals