Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

Autor: Chenxu Yan, Zhiqian Guo, Weijie Chi, Wei Fu, Syed Ali Abbas Abedi, Xiaogang Liu, He Tian, Wei-Hong Zhu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-24187-5
Popis: The electron-withdrawing target (EWT)-induced fluorescence quenching is an unsolved issue in intramolecular charge transfer (ICT) fluorophores that limits their applicability. Here, the authors report a simple and generalizable strategy to reverse the EWT-induced quenching mode into light-up mode, by introducing an indazole building block between the π-bridge and the donor in the ICT scaffold.
Databáze: Directory of Open Access Journals