Effect of hyaluronic acid on cytokines and immune cells change in patients of knee osteoarthritis

Autor:	Lixia Jin, Kangli Xu, Yun Liang, Peng Du, Shengcheng Wan, Chang Jiang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Knee osteoarthritis Hyaluronic acid Macrophages through polarization Diseases of the musculoskeletal system RC925-935
Zdroj:	BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-9 (2022)
Druh dokumentu:	article
ISSN:	1471-2474
DOI:	10.1186/s12891-022-05767-y
Popis:	Abstract Purpose To evaluate the changes of cytokines and immune cells after Intra-articular hyaluronic acid(IAHA)injections in patients with knee osteoarthritis (KOA). Patients and Methods Sixteen patients were included in the study, with a total of 65 IAHA injections. The Numeric Rating Scale (NRS) and Lysholm scores were evaluated at each visit. The immune cells and 14 cytokines of synovial fluid were analyzed at each visit. The association between immune cells and cytokines were examined. Results IL-6 and IL-8 were the most common cytokines in the synovial fluid of KOA patients. The synovial fluid was orchestrated by macrophages (69%) and Lymphocytes (18%). Neutrophils were less to count of the total cell population (
Databáze:	Directory of Open Access Journals
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