Research progress of mitochondrial ferritin and age-related macular degeneration

Autor: Zhi-Yu Xu, Jing Dong, Lu Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Guoji Yanke Zazhi, Vol 20, Iss 12, Pp 2083-2086 (2020)
Druh dokumentu: article
ISSN: 1672-5123
DOI: 10.3980/j.issn.1672-5123.2020.12.14
Popis: Age-related macular degeneration(ARMD)is a major cause of irreversible visual impairment in the elderly in developed countries. Recent studies have shown that mitochondrial ferritin(FTMT)is thought to have an antioxidant effect through iron regulation. Therefore, this paper discusses the effects of FTMT on HIF-1α, FTMT gene mutation, and FTMT protection against oxidative stress on the progression of ARMD, so as to better understand the pathogenesis of the disease and contribute to the prevention or evaluation of the disease.
Databáze: Directory of Open Access Journals