| Autor: |
Jarrin D. Penny, Patricia Jarosz, Fabio R. Salerno, Sandrine Lemoine, Christopher W. McIntyre |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Kidney Medicine, Vol 3, Iss 6, Pp 992-1002.e1 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0595 |
| DOI: |
10.1016/j.xkme.2021.05.010 |
| Popis: |
Rationale & Objective: Current hemodialysis (HD) treatments have limited ability to clear larger-molecular-weight uremic toxins. Retention is associated with increased symptom burden, low health-related quality of life (HRQoL), and high mortality. Improved clearance, using novel medium cut-off dialyzers, termed expanded HD (HDx), may be associated with improved subjective experience. We have previously developed a dynamic patient-reported outcome measure (PROM) instrument to allow iterative recording to better appreciate the overall burden of disease and assess the impact of therapy changes. Study Design: Single-center interventional pilot study. Setting & Participants: 28 patients established on maintenance HD, London, Ontario, Canada. Intervention: Initial study consisting of 2-week observation (baseline-conventional high-flux HD) followed by 12 weeks of HDx. HRQoL was assessed using the dynamic PROM instrument thrice weekly (enabled in a dedicated app as the London Evaluation of Illness [LEVIL]). Extension phase; 2-week baseline with 24 weeks of HDx and 8-week washout. Outcomes: Principal aim was to establish whether HDx therapy was associated with improved HRQoL, evidence of dose-dependant response, and whether effects were durable over time, using LEVIL. Results: Patients with lower LEVIL scores ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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