Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia
| Autor: | Gesine Bug, Kerstin Schwarz, Claudia Schoch, Manuela Kampfmann, Reinhard Henschler, Dieter Hoelzer, Oliver G. Ottmann, Martin Ruthardt |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 92, Iss 4 (2007) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.10758 |
| Popis: | Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested. |
| Databáze: | Directory of Open Access Journals |
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