Bioactive isochromenone isolated from Aspergillus fumigatus, endophytic fungus from Bacopa monnieri

Autor:	Jay Prakash Thakur, Rumana Haider, Dhananjay Kumar Singh, Balagani Sathish Kumar, Prema G. Vasudev, Suaib Luqman, Alok Kalra, Dharmendra Saikia, Arvind S. Negi
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Bacopa monnieri Aspergillus fumigatus endophyte isochromenone antioxidant Microbiology QR1-502
Zdroj:	Microbiology Research, Vol 6, Iss 1 (2015)
Druh dokumentu:	article
ISSN:	2036-7473 2036-7481
DOI:	10.4081/mr.2015.5800
Popis:	Fungal endophytes are a significant reservoir of novel bioactive secondary metabolites. Present communication describes isolation and structure determination of isochromenone, from endophytic microorganism Aspergillus fumigatus hosted in Bacopa monnieri plant. Further, its biological evaluation revealed it as antioxidant and antitubercular. The methanol extract of A. fumigatus inhibits the growth of the virulent strain of Mycobacterium tuberculosis H37RV with minimum inhibitory concentration 500 μg/mL. This is the first report of isolation of isochromenone from A. fumigatus.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/70d3e77283be4f1aa2f98e477c7a6d26 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF