Aurora A drives early signalling and vesicle dynamics during T-cell activation

Autor: Noelia Blas-Rus, Eugenio Bustos-Morán, Ignacio Pérez de Castro, Guillermo de Cárcer, Aldo Borroto, Emilio Camafeita, Inmaculada Jorge, Jesús Vázquez, Balbino Alarcón, Marcos Malumbres, Noa B. Martín-Cófreces, Francisco Sánchez-Madrid
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms11389
Popis: Aurora A is a protein kinase that contributes to the progression of mitosis by stimulating microtubule nucleation. Here the authors show that Aurora A also functions during T cell activation by maintaining TCR signaling through Lck activation.
Databáze: Directory of Open Access Journals