| Autor: |
Xuejun Kong, Junli Zhu, Ruiyi Tian, Siyu Liu, Hannah T. Sherman, Xiaoying Zhang, Xiaojing Lin, Yan Han, Zhi Xiang, Madelyn Koh, Clara Hobbie, Bryan Wang, Kevin Liu, Jun Liu, Yueping Yin, Guobin Wan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Frontiers in Psychiatry, Vol 11 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1664-0640 |
| DOI: |
10.3389/fpsyt.2020.594934 |
| Popis: |
Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height (P = 0.0186), overweight (P = 0.0248), and obstructive sleep apnea (P = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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