| Autor: |
Mayuri P Kannan, Sarojini Sreeraman, Selvaraj Arokiyaraj, Vickram Sundaram, Raja Babu Singh Kushwah, Giridharan Bupesh, Mayur Mausoom Phukan, Agastian Paul, Anand Thirunavukarasou, Mikhlid H. Almutairi, Nicholas Daniel Amalorpavanaden |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of King Saud University: Science, Vol 36, Iss 1, Pp 102956- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1018-3647 |
| DOI: |
10.1016/j.jksus.2023.102956 |
| Popis: |
Ficus racemosa has long been used as a treatment for bacterial and fungal infections by people in India. The search for a safe alternative therapy from plant resources has gained interest in recent years due to herb’s more central place in contemporary medicine and their status as a vast global reservoir of potentially active pharmaceuticals. Using standard methods, we aim to evaluate the pharmacological and bioactive potential of F. racemosa compounds extracted from fruits. Our observation reveals that stigmasterol has the highest docking score across all targets, making it the most promising chemical overall. According to Lipinski's rule of thumb, the obtained compounds derived from F. racemosa were predicted to have high bioactivities, giving them a high drug-likeliness score. Target and compound docking scores provide insight into binding posture and critical amino acid residues in antibacterial and antifungal activity. This research confirms that F. racemosa fruit extract is effective against fungal infections. These findings will aid biochemists in their quest to produce effective phytochemicals by further testing multi-targeting drugs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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