ATP-sensitive potassium channels gene polymorphism rs1799858 affects the risk of macro-/micro-vascular arteriosclerotic event in patients with increased low-density lipoprotein cholesterol levels

Autor: Cheng Liu, Tianwang Guan, Yanxian Lai, Jieming Zhu, Jian Kuang, Yan Shen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 1476-511X
DOI: 10.1186/s12944-020-01315-6
Popis: Abstract Background Plasma concentration of low-density lipoprotein cholesterol (LDL-C) is causally related to the risk of arteriosclerotic events. Whether ATP-sensitive potassium channels (KATP) genetic variants predict increased LDL-C concentration (≥1.8 mmol/L) and risk of macro-/micro-vascular arteriosclerotic event remain elusive. Methods A total of 320 subjects with increased LDL-C concentration (≥1.8 mmol/L) and 320 counterpart subjects (
Databáze: Directory of Open Access Journals
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