Effect of Virtual Reality Hypnosis on Pain Threshold and Neurophysiological and Autonomic Biomarkers in Healthy Volunteers: Prospective Randomized Crossover Study

Autor: Claire Terzulli, Meggane Melchior, Laurent Goffin, Sylvain Faisan, Coralie Gianesini, Denis Graff, André Dufour, Edouard Laroche, Chloé Chauvin, Pierrick Poisbeau
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical Internet Research, Vol 24, Iss 7, p e33255 (2022)
Druh dokumentu: article
ISSN: 1438-8871
DOI: 10.2196/33255
Popis: BackgroundVirtual reality hypnosis (VRH) is a promising tool to reduce pain. However, the benefits of VRH on pain perception and on the physiological expression of pain require further investigation. ObjectiveIn this study, we characterized the effects of VRH on the heat pain threshold among adult healthy volunteers while monitoring several physiological and autonomic functions. MethodsSixty healthy volunteers were prospectively included to receive nociceptive stimulations. The first set of thermal stimuli consisted of 20 stimulations at 60°C (duration 500 milliseconds) to trigger contact heat evoked potentials (CHEPs). The second set of thermal stimuli consisted of ramps (1°C/second) to determine the heat pain threshold of the participants. Electrocardiogram, skin conductance responses, respiration rate, as well as the analgesia nociception index were also recorded throughout the experiment. ResultsData from 58 participants were analyzed. There was a small but significant increase in pain threshold in VRH (50.19°C, SD 1.98°C) compared to that in the control condition (mean 49.45°C, SD 1.87; P0.5; n=22 and n=52, respectively). During VRH, participants exhibited a clear reduction in their autonomic sympathetic tone, as shown by the lower number of nonspecific skin conductance peak responses (P
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