Isoimperatorin alleviates acetic acid–induced colitis in rats
| Autor: | Goodarzi Saied, Abdolghaffari Amir Hossein, Najafi Behnaz, Pirali Hamedani Mostafa, Tavakoli Saeed, Marvi Mahshad, Baeeri Maryam, Yassa Narguess, Hadjiakhoondi Abbas, Abdollahi Mohammad, Tofighi Zahra |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 4, Pp 147-153 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2221-1691 2588-9222 |
| DOI: | 10.4103/apjtb.apjtb_851_23 |
| Popis: | Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis. |
| Databáze: | Directory of Open Access Journals |
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